(R)-6-hydroxynicotine oxidase

Template:Short description Template:Infobox enzyme In enzymology, a (R)-6-hydroxynicotine oxidase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(R)-6-hydroxynicotine + HTemplate:SubO + OTemplate:Sub $\rightleftharpoons$ 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + HTemplate:SubOTemplate:Sub

The 3 substrates of this enzyme are (R)-6-hydroxynicotine, [[water|HTemplate:SubO]], and [[oxygen|OTemplate:Sub]], whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and [[hydrogen peroxide|HTemplate:SubOTemplate:Sub]].

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

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