Methylenetetrahydrofolate dehydrogenase (NAD+)

Template:Infobox enzyme In enzymology, a methylenetetrahydrofolate dehydrogenase (NAD⁺) (Template:EC number) is an enzyme that catalyzes a chemical reaction.

5,10-methylenetetrahydrofolate + NAD⁺ $\rightleftharpoons$ 5,10-methenyltetrahydrofolate + NADH + H⁺

Thus, the two substrates of this enzyme are 5,10-methylenetetrahydrofolate and NAD⁺, whereas its 3 products are 5,10-methenyltetrahydrofolate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:NAD⁺ oxidoreductase. This enzyme is also called methylenetetrahydrofolate dehydrogenase (NAD⁺). This enzyme participates in one carbon pool by folate.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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