Glutamate synthase (ferredoxin)

Template:Infobox enzyme In enzymology, a glutamate synthase (ferredoxin) (Template:EC number) is an enzyme that catalyzes the chemical reaction

2 L-glutamate + 2 oxidized ferredoxin $\rightleftharpoons$ L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H⁺

Thus, the two substrates of this enzyme are L-glutamate and oxidized ferredoxin, whereas its 4 products are L-glutamine, 2-oxoglutarate, reduced ferredoxin, and H⁺.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH₂ group of donors with an iron-sulfur protein as acceptor.

Nomenclature

The systematic name of this enzyme class is L-glutamate:ferredoxin oxidoreductase (transaminating). Other names in common use include:

• ferredoxin-dependent glutamate synthase,
• ferredoxin-glutamate synthase,
• glutamate synthase (ferredoxin-dependent), and
• ferredoxin-glutamine oxoglutarate aminotransferase (Fd-GOGAT).

Biological role

This enzyme participates in nitrogen metabolism. It has 5 cofactors: FAD, iron, sulfur, iron-sulfur, and flavoprotein.

See also

• Glutamate synthase (NADH)
• Glutamate synthase (NADPH)

References

• Template:Cite journal
• Template:Cite journal

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