Diaminopimelate dehydrogenase

Template:Infobox enzyme In enzymology, a diaminopimelate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

meso-2,6-diaminoheptanedioate + H₂O + NADP⁺ $\rightleftharpoons$ L-2-amino-6-oxoheptanedioate + NH₃ + NADPH + H⁺

The 3 substrates of this enzyme are meso-2,6-diaminoheptanedioate, H₂O, and NADP⁺, whereas its 4 products are L-2-amino-6-oxoheptanedioate, NH₃, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating). Other names in common use include meso-alpha,epsilon-diaminopimelate dehydrogenase, and meso-diaminopimelate dehydrogenase. This enzyme participates in lysine biosynthesis.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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