2-oxopropyl-CoM reductase (carboxylating)

Template:Short description Template:Infobox enzyme In enzymology, a 2-oxopropyl-CoM reductase (carboxylating) (Template:EC number) is an enzyme that catalyzes the chemical reaction

2-mercaptoethanesulfonate + acetoacetate + NADP⁺ $\rightleftharpoons$ 2-(2-oxopropylthio)ethanesulfonate + CO₂ + NADPH

The 3 substrates of this enzyme are 2-mercaptoethanesulfonate, acetoacetate, and NADP⁺, whereas its 3 products are 2-(2-oxopropylthio)ethanesulfonate, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-mercaptoethanesulfonate, acetoacetate:NADP+ oxidoreductase (decarboxylating). Other names in common use include NADPH:2-(2-ketopropylthio)ethanesulfonate, oxidoreductase/carboxylase, and NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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