Tryptophan 2'-dioxygenase

Template:Infobox enzyme In enzymology, a tryptophan 2'-dioxygenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

L-tryptophan + Template:Chem + Template:Chem $\rightleftharpoons$ (indol-3-yl)glycolaldehyde + Template:Chem + Template:Chem

Thus, the 3 substrates of this enzyme are L-tryptophan, [[oxygen|Template:Chem]] and [[hidrogen ion|Template:Chem]], whereas its 3 products are (indol-3-yl)glycolaldehyde, [[carbon dioxide|Template:Chem]], and [[ammonium|Template:Chem]].

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O miscellaneous.

Nomenclature

The systematic name of this enzyme class is L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving). Other names in common use include indole-3-alkane alpha-hydroxylase, tryptophan side-chain alpha,beta-oxidase, tryptophan side chain oxidase II, tryptophan side-chain oxidase, TSO, indolyl-3-alkan alpha-hydroxylase, tryptophan side chain oxidase type I, TSO I, TSO II, and tryptophan side chain oxidase.

Biological role

This enzyme participates in tryptophan metabolism. It employs one cofactor, heme.

References

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