Arsenate reductase (azurin)

Template:Infobox enzyme Arsenate reductase (azurin) (Template:EC number) is an enzyme that catalyzes the chemical reaction

arsenite + H₂O + 2 azurin_ox $\rightleftharpoons$ arsenate + 2 azurin_red + 2 H⁺

The 3 substrates of this enzyme are arsenite, water, and oxidised azurin, whereas its 3 products are arsenate, reduced azurin, and hydrogen ion.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with a copper protein as acceptor.

Nomenclature

The systematic name of this enzyme class is arsenite:azurin oxidoreductase. This enzyme is also called arsenite oxidase.

Structure and function

The enzyme contains a molybdopterin centre comprising two molybdopterin guanosine dinucleotide cofactors bound to molybdenum, a [3Fe-4S] cluster and a Rieske-type [2Fe-2S] cluster. Also uses a c-type cytochrome or Template:Chem as acceptors.

References

• Template:Cite journal
• Template:Cite journal