Succinate-semialdehyde dehydrogenase (NAD(P)+)

Template:Infobox enzyme In enzymology, a succinate-semialdehyde dehydrogenase [NAD(P)+] (Template:EC number) is an enzyme that catalyzes the chemical reaction

succinate semialdehyde + NAD(P)+ + H₂O $\rightleftharpoons$ succinate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are succinate semialdehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are succinate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate-semialdehyde:NAD(P)+ oxidoreductase. Other names in common use include succinate semialdehyde dehydrogenase (nicotinamide adenine, dinucleotide (phosphate)), and succinate-semialdehyde dehydrogenase [NAD(P)+]. This enzyme participates in 3 metabolic pathways: glutamate metabolism, tyrosine metabolism, and butanoate metabolism.

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
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