(R)-dehydropantoate dehydrogenase

Template:Short description Template:No footnotes Template:Infobox enzyme In enzymology, a (R)-dehydropantoate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(R)-4-dehydropantoate + NADTemplate:Sup + HTemplate:SubO $\rightleftharpoons$ (R)-3,3-dimethylmalate + NADH + 2 HTemplate:Sup

The 3 substrates of this enzyme are (R)-4-dehydropantoate, [[nicotinamide adenine dinucleotide|NADTemplate:Sup]], and [[water|HTemplate:SubO]], whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and [[hydrogen ion|HTemplate:Sup]].

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

References

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