Oxoglutarate dehydrogenase (NADP+)

Template:Infobox enzyme In enzymology, an oxoglutarate dehydrogenase (NADP+) (Template:EC number) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP⁺ $\rightleftharpoons$ succinyl-CoA + CO₂ + NADPH

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP⁺, whereas its 3 products are succinyl-CoA, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).

References

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