Lactaldehyde dehydrogenase

Template:Infobox enzyme In enzymology, a lactaldehyde dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(S)-lactaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ (S)-lactate + NADH + 2 H⁺

The 3 substrates of this enzyme are (S)-lactaldehyde, NAD⁺, and H₂O, whereas its 3 products are (S)-lactate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-lactaldehyde:NAD+ oxidoreductase. Other names in common use include L-lactaldehyde:NAD+ oxidoreductase, and nicotinamide adenine dinucleotide (NAD+)-linked dehydrogenase. This enzyme participates in pyruvate metabolism.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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