Formate dehydrogenase (NADP+)

Template:Short description Template:Infobox enzyme In enzymology, a formate dehydrogenase (NADP+) (Template:EC number) is an enzyme that catalyzes the chemical reaction

formate + NADP⁺ $\rightleftharpoons$ CO₂ + NADPH

Thus, the two substrates of this enzyme are formate and NADP⁺, whereas its two products are CO₂ and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is formate:NADP+ oxidoreductase. Other names in common use include NADP+-dependent formate dehydrogenase, and formate dehydrogenase (NADP+). This enzyme participates in methane metabolism. It has 3 cofactors: iron, Tungsten, and Selenium.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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