(S)-canadine synthase
Template:Short description Template:Infobox enzyme In enzymology, a (S)-canadine synthase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- (S)-tetrahydrocolumbamine + NADPH + HTemplate:Sup + OTemplate:Sub (S)-canadine + NADPTemplate:Sup + 2 HTemplate:SubO
The 4 substrates of this enzyme are (S)-tetrahydrocolumbamine, NADPH, [[hydrogen ion|HTemplate:Sup]], and [[oxygen|OTemplate:Sub]], whereas its 3 products are Canadine, [[nicotinamide adenine dinucleotide phosphate|NADPTemplate:Sup]], and [[water|HTemplate:SubO]].
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with OTemplate:Sub as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from OTemplate:Sub with NADH or NADPH as one donor, and the other dehydrogenated. The systematic name of this enzyme class is (S)-tetrahydrocolumbamine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming). Other names in common use include (S)-tetrahydroberberine synthase, and (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming). This enzyme participates in alkaloid biosynthesis i. It employs one cofactor, heme-thiolate(P-450).