Precorrin-2 dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a precorrin-2 dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

precorrin-2 + NAD⁺ $\rightleftharpoons$ sirohydrochlorin + NADH + H⁺

Precorrin-2

Sirohydrochlorin

The two substrates of this enzyme are precorrin-2 and NAD⁺; its three products are sirohydrochlorin, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is precorrin-2:NAD+ oxidoreductase. Other names in common use include Met8p, SirC, and CysG. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria and to Cofactor F430.

See also

• Cobalamin biosynthesis

References

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• Template:Cite journal

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