Orotate reductase (NADH)

Template:Short description Template:Infobox enzyme In enzymology, an orotate reductase (NADH) (Template:EC number) is an enzyme that catalyzes the chemical reaction

(S)-dihydroorotate + NAD⁺ $\rightleftharpoons$ orotate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NAD⁺, whereas its 3 products are orotate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NAD+ oxidoreductase. This enzyme is also called orotate reductase (NADH). This enzyme participates in pyrimidine metabolism. It has 2 cofactors: FAD, and FMN.

References

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