TRNA (guanine-N1-)-methyltransferase

Template:Infobox enzyme Template:Lowercase title In enzymology, a tRNA (guanine-N1-)-methyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA $\rightleftharpoons$ S-adenosyl-L-homocysteine + tRNA containing N₁-methylguanine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methylguanine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate guanine 1-methyltransferase, tRNA guanine 1-methyltransferase, and S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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