MRNA (guanine-N7-)-methyltransferase
Template:Short description Template:Lowercase title Template:Infobox enzyme Template:Infobox gene In enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + G(5')pppR-RNA S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)
Thus, the two substrates of this enzyme are S-adenosyl methionine and G(5')pppR-RNA, whereas its two products are S-adenosylhomocysteine and m7G(5')pppR-RNA. This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases.
In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT gene.[1][2][3]
Nomenclature
The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:
- messenger ribonucleate guanine 7-methyltransferase,
- guanine-7-methyltransferase,
- messenger RNA guanine 7-methyltransferase, and
- S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.
- cap MTase
See also
References
Further reading
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