2-hydroxymethylglutarate dehydrogenase

In enzymology, a 2-hydroxymethylglutarate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(S)-2-hydroxymethylglutarate + NAD⁺ $\rightleftharpoons$ 2-formylglutarate + NADH + H⁺

Thus, the two substrates of this enzyme are (S)-2-hydroxymethylglutarate and NAD⁺, whereas its 3 products are 2-formylglutarate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxymethylglutarate:NAD⁺ oxidoreductase. This enzyme is also called HgD.

References

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