15-hydroxyicosatetraenoate dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 15-hydroxyicosatetraenoate dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)+

⇌

15-oxo-5,8,11-cis-13-trans-icosatetraenoate + NAD(P)H + H⁺

The 3 substrates of this enzyme are 15-hydroxyicosatetraenoic acid (i.e. 15(S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate), NAD⁺, and NADP⁺, whereas its 4 products are 15-oxo-5,8,11-cis-13-trans-icosatetraenoate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)⁺ 15-oxidoreductase. This enzyme is also called 15-hydroxyeicosatetraenoate dehydrogenase. This enzyme participates in arachidonic acid metabolism.