Choline-phosphate cytidylyltransferase

Template:Infobox enzyme Choline-phosphate cytidylyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

CTP + choline phosphate $\rightleftharpoons$ diphosphate + CDP-choline

where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP-choline. It is responsible for regulating phosphatidylcholine content in membranes.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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