Acetylglutamate kinase

Template:Short description Template:Infobox enzyme In enzymology, an acetylglutamate kinase (Template:EC number) is an enzyme that catalyzes the chemical reaction:

ATP + N-acetyl-L-glutamate $\rightleftharpoons$ ADP + N-acetyl-L-glutamyl 5-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-L-glutamate, whereas its two products are ADP and N-acetyl-L-glutamyl 5-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. This enzyme participates in urea cycle and metabolism of amino groups.

Nomenclature

The systematic name of this enzyme class is ATP:N-acetyl-L-glutamate 5-phosphotransferase. Other names in common use include:

• N-acetylglutamate 5-phosphotransferase,
• acetylglutamate phosphokinase,
• N-acetylglutamate phosphokinase,
• N-acetylglutamate kinase, and
• N-acetylglutamic 5-phosphotransferase.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal
• Template:Cite journal
• Template:Cite book

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