Pyrimidine-nucleoside phosphorylase

Template:Short description Template:Infobox enzyme In enzymology, a pyrimidine-nucleoside phosphorylase (Template:EC number) is an enzyme that catalyzes the chemical reaction

a pyrimidine nucleoside + phosphate $\rightleftharpoons$ a pyrimidine base + alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are pyrimidine nucleoside and phosphate, whereas its two products are pyrimidine base and alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase. This enzyme is also called Py-NPase. This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 5, Academic Press, New York, 1961, p. 237-255.
• Template:Cite journal
• Template:Cite journal

Template:2.4-enzyme-stub