Guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Template:Short description Template:Infobox enzyme In enzymology, a guanosine-5'-triphosphate,3'-diphosphate diphosphatase (Template:EC number) is an enzyme that catalyzes the chemical reaction

guanosine 5'-triphosphate,3'-diphosphate + H₂O $\rightleftharpoons$ guanosine 5'-diphosphate,3'-diphosphate + phosphate

Thus, the two substrates of this enzyme are guanosine 5'-triphosphate,3'-diphosphate and H₂O, whereas its two products are guanosine 5'-diphosphate,3'-diphosphate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase. Other names in common use include pppGpp 5'-phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase, and guanosine pentaphosphate phosphohydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007Template:Update inline, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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