Phenylacetate—CoA ligase

Template:One source Template:Infobox enzyme In enzymology, a phenylacetate—CoA ligase is an enzyme (Template:EnzExplorer) that catalyzes the chemical reaction

ATP + phenylacetate + CoA $\rightleftharpoons$ AMP + diphosphate + phenylacetyl-CoA

The 3 substrates of this enzyme are ATP, phenylacetate, and CoA. Its 3 products are AMP, diphosphate, and phenylacetyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is phenylacetate:CoA ligase (AMP-forming). Other names in common use include phenylacetyl-CoA ligase, PA-CoA ligase, and phenylacetyl-CoA ligase (AMP-forming). This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

References

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