Glutarate—CoA ligase

Template:Infobox enzyme In enzymology, a glutarate—CoA ligase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction

ATP + glutarate + CoA $\rightleftharpoons$ ADP + phosphate + glutaryl-CoA

The 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is glutarate:CoA ligase (ADP-forming). Other names in common use include glutaryl-CoA synthetase, and glutaryl coenzyme A synthetase. This enzyme participates in fatty acid metabolism and lysine degradation.

References

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