Gamma-glutamylhistamine synthase

Template:Short description Template:Infobox enzyme In enzymology, a γ-glutamylhistamine synthase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction

ATP + L-glutamate + histamine $\rightleftharpoons$ products of ATP breakdown + N^α-γ-L-glutamylhistamine

The 3 substrates of this enzyme are ATP, L-glutamate, and histamine, whereas its two products are products of ATP breakdown and Nalpha-gamma-L-glutamylhistamine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-glutamate:histamine ligase. Other names in common use include gamma-glutaminylhistamine synthetase, and gamma-GHA synthetase.

References

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