Formate—dihydrofolate ligase

Template:Infobox enzyme In enzymology, a formate—dihydrofolate ligase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction

ATP + formate + dihydrofolate $\rightleftharpoons$ ADP + phosphate + 10-formyldihydrofolate

The 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate.

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is formate:dihydrofolate ligase (ADP-forming).

Further reading

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