2-dehydro-3-deoxyglucarate aldolase

Template:Short description Template:Infobox enzyme The enzyme 2-dehydro-3-deoxyglucarate aldolase (Template:EnzExplorer) catalyzes the chemical reaction

2-dehydro-3-deoxy-D-glucarate $\rightleftharpoons$ pyruvate + tartronate semialdehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite book

Template:4.1-enzyme-stub