Deoxycytidylate 5-hydroxymethyltransferase

Template:Infobox enzyme In enzymology, a deoxycytidylate 5-hydroxymethyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

5,10-methylenetetrahydrofolate + H₂O + deoxycytidylate $\rightleftharpoons$ tetrahydrofolate + 5-hydroxymethyldeoxycytidylate

The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, H₂O, and deoxycytidylate, whereas its two products are tetrahydrofolate and 5-hydroxymethyldeoxycytidylate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase. Other names in common use include dCMP hydroxymethylase, d-cytidine 5'-monophosphate hydroxymethylase, deoxyCMP hydroxymethylase, deoxycytidylate hydroxymethylase, and deoxycytidylic hydroxymethylase. This enzyme participates in pyrimidine metabolism and one carbon pool by folate.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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