Pyrroline-5-carboxylate reductase

Template:Infobox enzyme In enzymology, a pyrroline-5-carboxylate reductase (Template:EC number) is an enzyme that catalyzes the chemical reaction

L-proline + NAD(P)+ $\rightleftharpoons$ 1-pyrroline-5-carboxylate + NAD(P)H + H⁺

The 3 substrates of this enzyme are L-proline, NAD⁺, and NADP⁺, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 5-oxidoreductase. Other names in common use include proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and L-proline-NAD(P)+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

Human genes

• PYCR1, nuclear gene for mitochondrial protein
• PYCR2, nuclear gene for mitochondrial protein
• PYCR3 (formerly PYCRL), cytosolic protein

References

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