HAAO

Template:Short description Template:Infobox gene Template:Infobox enzyme 3-hydroxyanthranilate 3,4-dioxygenase (Template:EC number) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction

3-hydroxyanthranilate + O₂ $\rightleftharpoons$ 2-amino-3-carboxymuconate semialdehyde

Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O₂, whereas its product is 2-amino-3-carboxymuconate semialdehyde.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂.

The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase and 3HAO. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.h

References

• Template:Cite journal
• Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.