Malate dehydrogenase (decarboxylating)

Template:Short description Template:Infobox enzyme Malate dehydrogenase (decarboxylating) (Template:EC number) or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD⁺ $\rightleftharpoons$ pyruvate + CO₂ + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD⁺, whereas its three products are pyruvate, CO₂, and NADH. Malate is oxidized to pyruvate and CO₂, and NAD⁺ is reduced to NADH.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD⁺ oxidoreductase (decarboxylating). This enzyme participates in pyruvate metabolism and carbon fixation. NAD-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C₄ and CAM plants. The others are NADP-malic enzyme and PEP carboxykinase.

References

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