View source for Valine dehydrogenase (NAD+)

{{Infobox enzyme
| Name       = Valine dehydrogenase (NAD<sup>+</sup>)
| EC_number  = 1.4.1.23
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Valine dehydrogenase (NAD<sup>+</sup>)''' ({{EC number|1.4.1.23}}) is an [[enzyme]] with [[List of enzymes|systematic name]] ''L-valine:NAD<sup>+</sup> oxidoreductase (deaminating)''.<ref>{{cite journal | vauthors = Vancurová I, Vancura A, Volc J, Neuzil J, Flieger M, [[Gabriela Basařová|Basarová G]], Bĕhal V | title = Isolation and characterization of valine dehydrogenase from Streptomyces aureofaciens | journal = Journal of Bacteriology | volume = 170 | issue = 11 | pages = 5192–6 | date = November 1988 | pmid = 3182727 | pmc = 211589 | doi = 10.1128/jb.170.11.5192-5196.1988 }}</ref><ref>{{cite journal | vauthors = Navarrete RM, Vara JA, Hutchinson CR | title = Purification of an inducible L-valine dehydrogenase of Streptomyces coelicolor A3(2) | journal = Journal of General Microbiology | volume = 136 | issue = 2 | pages = 273–81 | date = February 1990 | pmid = 2324704 | doi = 10.1099/00221287-136-2-273 | doi-access = free }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: L-valine + H<sub>2</sub>O + NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-methyl-2-oxobutanoate + NH<sub>3</sub> + NADH + H<sup>+</sup>

The enzyme from ''[[Streptomyces]]'' spp. has no activity with NADP<sup>+</sup>.

== See also ==
* [[Valine dehydrogenase (NADP+)]]

== References ==
{{reflist}}

== External links ==
* {{MeshName|Valine+dehydrogenase+(NAD+)}}

{{CH-NH2 oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.4.1]]