View source for Trimethylamine-N-oxide reductase (cytochrome c)

{{infobox enzyme
| Name       = trimethylamine-N-oxide reductase (cytochrome c)
| EC_number  = 1.7.2.3
| CAS_number = 37256-34-1
| GO_code    = 0050626
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''trimethylamine-N-oxide reductase (cytochrome c)''' ({{EC number|1.7.2.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:trimethylamine + 2 (ferricytochrome c)-subunit + H<sub>2</sub>O <math>\rightleftharpoons</math> trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H<sup>+</sup>

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[trimethylamine]], [[(ferricytochrome c)-subunit]], and [[water|H<sub>2</sub>O]], whereas its 3 [[product (chemistry)|products]] are [[trimethylamine N-oxide]], [[(ferrocytochrome c)-subunit]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on other nitrogenous compounds as donors with a cytochrome as acceptor.  The [[List of enzymes|systematic name]] of this enzyme class is '''trimethylamine:cytochrome c oxidoreductase'''. Other names in common use include '''TMAO reductase''', and '''TOR'''.  This enzyme participates in [[two-component system - general]].

==References==
{{reflist|1}}
* {{cite journal | vauthors = Arata H, Shimizu M, Takamiya K | location = Tokyo | title = Purification and properties of trimethylamine N-oxide reductase from aerobic photosynthetic bacterium Roseobacter denitrificans | journal = J. Biochem. | volume = 112| pages = 470&ndash;5  | pmid = 1337081 | issue = 4 | date=October 1992}}
* {{cite journal | doi = 10.1515/bchm.1997.378.3-4.293 | vauthors = Knablein J, Dobbek H, Ehlert S, Schneider F | date = 1997 | title = Isolation, cloning, sequence analysis and X-ray structure of dimethyl sulfoxide/trimethylamine N-oxide reductase from Rhodobacter capsulatus | journal = Biol. Chem.  | volume = 378 | pages = 293&ndash;302  | pmid = 9165084 | issue = 3–4 }}
* {{cite journal | vauthors = Czjzek M, Dos Santos JP, Pommier J, Giordano G, Mejean V, Haser R | date = 1998 | title = Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 A resolution | journal = J. Mol. Biol.  | volume = 284 | pages = 435&ndash;47  | pmid = 9813128 | doi = 10.1006/jmbi.1998.2156 | issue = 2 }}
* {{cite journal | vauthors = Gon S, Giudici-Orticoni MT, Mejean V, Iobbi-Nivol C | date = 2001 | title = Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli | journal = J. Biol. Chem.  | volume = 276 | pages = 11545&ndash;51  | pmid = 11056172 | doi = 10.1074/jbc.M008875200 | issue = 15 | doi-access = free }}

{{Nitrogenous donor oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.7.2]]
[[Category:Enzymes of unknown structure]]


{{1.7-enzyme-stub}}