View source for Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase

{{Infobox enzyme
| Name       = ''trans-o''-Hydroxybenzylidenepyruvate hydratase-aldolase
| EC_number  = 4.1.2.45
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''''trans-o''-Hydroxybenzylidenepyruvate hydratase-aldolase''' ({{EnzExplorer|4.1.2.45}}, ''2′-hydroxybenzalpyruvate aldolase'', ''NsaE'', ''tHBPA hydratase-aldolase'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase''.<ref>{{cite journal | vauthors = Kuhm AE, Knackmuss HJ, Stolz A | title = Purification and properties of 2'-hydroxybenzalpyruvate aldolase from a bacterium that degrades naphthalenesulfonates | journal = The Journal of Biological Chemistry | volume = 268 | issue = 13 | pages = 9484–9 | date = May 1993 | pmid = 8486638 }}</ref><ref>{{cite journal | vauthors = Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J | title = Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6 | journal = Microbiology | volume = 152 | issue = Pt 7 | pages = 1929–40 | date = July 2006 | pmid = 16804169 | doi = 10.1099/mic.0.28783-0 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Eaton RW | title = Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid | journal = Journal of Bacteriology | volume = 176 | issue = 24 | pages = 7757–62 | date = December 1994 | pmid = 8002605 | pmc = 197239 | doi = 10.1128/jb.176.24.7757-7762.1994 }}</ref><ref>{{cite journal | vauthors = Eaton RW | title = trans-o-Hydroxybenzylidenepyruvate hydratase-aldolase as a biocatalyst | journal = Applied and Environmental Microbiology | volume = 66 | issue = 6 | pages = 2668–72 | date = June 2000 | pmid = 10831455 | pmc = 110598 | doi = 10.1128/aem.66.6.2668-2672.2000 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate + H<sub>2</sub>O <math>\rightleftharpoons</math> [[salicylaldehyde]] + [[pyruvate]]

This enzyme is involved in [[naphthalene]] degradation.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Trans-o-hydroxybenzylidenepyruvate+hydratase-aldolase}}

{{Carbon-carbon lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 4.1.2]]