View source for TRNA (guanine10-N2)-methyltransferase

{{Infobox enzyme
| Name       = TRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase
| EC_number  = 2.1.1.214
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''TRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase''' ({{EC number|2.1.1.214}}, ''(m2G10) methyltransferase'', ''Trm11-Trm112 complex'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''S-adenosyl-L-methionine:tRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase''.<ref>{{cite journal | vauthors = Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B | title = Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA | journal = Molecular and Cellular Biology | volume = 25 | issue = 11 | pages = 4359–70 | date = June 2005 | pmid = 15899842 | pmc = 1140639 | doi = 10.1128/MCB.25.11.4359-4370.2005 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[guanine]]<sup>10</sup> in tRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + N<sup>2</sup>-methylguanine<sup>10</sup> in tRNA

tRNA (guanine<sup>10</sup>-N<sup>2</sup>)-methyltransferase from [[yeast]] does not catalyse the methylation from N<sup>2</sup>-methylguanine<sup>10</sup> to N<sup>2</sup>-dimethylguanine<sup>10</sup> in tRNA.

== References ==
{{reflist}}

== External links ==
* {{MeshName|TRNA+(guanine10-N2)-methyltransferase}}

{{One carbon transferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 2.1.1]]