View source for Sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)

{{infobox enzyme
| Name       = sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)
| EC_number  = 1.1.1.170
| CAS_number = 71822-23-6
| GO_code    = 0047012
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)''' ({{EC number|1.1.1.170}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate + NAD(P)<sup>+</sup> <math>\rightleftharpoons</math> 4alpha-methyl-5alpha-cholest-7-en-3-one + CO<sub>2</sub> + NAD(P)H

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[4alpha-methyl-5alpha-cholest-7-en-3-one]], [[carbon dioxide|CO<sub>2</sub>]], [[nicotinamide adenine dinucleotide|NADH]], and [[nicotinamide adenine dinucleotide phosphate|NADPH]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)<sup>+</sup> 3-oxidoreductase (decarboxylating)'''. Other names in common use include '''3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase''', '''(decarboxylating)''', '''3beta-hydroxy-4beta-methylcholestenoate dehydrogenase''', '''3beta-hydroxy-4beta-methylcholestenoate dehydrogenase''', and '''sterol 4alpha-carboxylic decarboxylase'''. This enzyme participates in [[biosynthesis of steroids]].

==References==
{{reflist|1}}
* {{cite journal |vauthors=Brady DR, Crowder RD, Hayes WJ | date = 1980 | title = Mixed function oxidases in sterol metabolism. Source of reducing equivalents | journal = J. Biol. Chem. | volume = 255 | pages = 10624&ndash;9 | pmid = 7430141 | issue = 22 }}
* {{cite journal |vauthors=Rahimtula AD, Gaylor JL | date = 1972 | title = Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase | journal = J. Biol. Chem. | volume = 247 | pages = 9&ndash;15 | pmid = 4401584 | issue = 1 }}

{{Alcohol oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.1.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]


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