View source for Pyruvate oxidase (CoA-acetylating)

{{technical|date=August 2016}}
{{infobox enzyme
| Name       = pyruvate oxidase (CoA-acetylating)
| EC_number  = 1.2.3.6
| CAS_number = 62213-57-4
| GO_code    = 0050244
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''pyruvate oxidase (CoA-acetylating)''' ({{EC number|1.2.3.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:pyruvate + CoA + O<sub>2</sub> <math>\rightleftharpoons</math> acetyl-CoA + CO<sub>2</sub> + H<sub>2</sub>O<sub>2</sub>

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[pyruvate]], [[coenzyme A|CoA]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[acetyl-CoA]], [[carbon dioxide|CO<sub>2</sub>]], and [[hydrogen peroxide|H<sub>2</sub>O<sub>2</sub>]].

This enzyme belongs to the family of [[oxidoreductase]]s , specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor.  The [[List of enzymes|systematic name]] of this enzyme class is '''pyruvate:oxygen 2 - oxidoreductase (CoA-acetylating)'''. This enzyme participates in [[pyruvate metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[flavin adenine dinucleotide|FAD]].

==References==
{{reflist|1}}
* {{cite journal | vauthors = Reeves RE, Warren LG, Susskind B, Lo HS | date = 1977 | title = An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase | journal = J. Biol. Chem.  | volume = 252 | pages = 726&ndash;31  | pmid = 13076 | issue = 2 | doi = 10.1016/S0021-9258(17)32778-3 | doi-access = free }}
* {{cite journal | vauthors = Takeuchi T, Weinbach EC, Diamond LS | date = 1975 | title = Pyruvate oxidase (CoA acetylating) in Entamoeba histolytica | journal = Biochem. Biophys. Res. Commun.  | volume = 65 | pages = 591&ndash;6  | pmid = 167776 | doi = 10.1016/S0006-291X(75)80187-2 | issue = 2 }}

{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.2.3]]
[[Category:Flavoproteins]]
[[Category:Enzymes of unknown structure]]


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