View source for Pyruvate dehydrogenase (quinone)

{{Infobox enzyme
| Name       = Pyruvate dehydrogenase (quinone)
| EC_number  = 1.2.5.1
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Pyruvate dehydrogenase (quinone)''' ({{EC number|1.2.5.1}}, ''pyruvate dehydrogenase'', ''pyruvic dehydrogenase'', ''pyruvic (cytochrome b1) dehydrogenase'', ''pyruvate:ubiquinone-8-oxidoreductase'', ''pyruvate oxidase (ambiguous)'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''pyruvate:ubiquinone oxidoreductase''.<ref>{{cite journal | vauthors = Recny MA, Hager LP | title = Reconstitution of native Escherichia coli pyruvate oxidase from apoenzyme monomers and FAD | journal = The Journal of Biological Chemistry | volume = 257 | issue = 21 | pages = 12878–86 | date = November 1982 | pmid = 6752142 }}</ref><ref>{{cite journal | vauthors = Cunningham CC, Hager LP | title = Reactivation of the lipid-depleted pyruvate oxidase system from Escherichia coli with cell envelope neutral lipids | journal = The Journal of Biological Chemistry | volume = 250 | issue = 18 | pages = 7139–46 | date = September 1975 | pmid = 1100621 }}</ref><ref>{{cite journal | vauthors = Koland JG, Miller MJ, Gennis RB | title = Reconstitution of the membrane-bound, ubiquinone-dependent pyruvate oxidase respiratory chain of Escherichia coli with the cytochrome d terminal oxidase | journal = Biochemistry | volume = 23 | issue = 3 | pages = 445–53 | date = January 1984 | pmid = 6367818 | doi = 10.1021/bi00298a008 }}</ref><ref>{{cite journal | vauthors = Grabau C, Cronan JE | title = In vivo function of Escherichia coli pyruvate oxidase specifically requires a functional lipid binding site | journal = Biochemistry | volume = 25 | issue = 13 | pages = 3748–51 | date = July 1986 | pmid = 3527254 | doi = 10.1021/bi00361a003 }}</ref><ref>{{cite journal | vauthors = Wang AY, Chang YY, Cronan JE | title = Role of the tetrameric structure of Escherichia coli pyruvate oxidase in enzyme activation and lipid binding | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 10959–66 | date = June 1991 | pmid = 2040613 }}</ref><ref>{{cite journal | vauthors = Chang YY, Cronan JE | title = Sulfhydryl chemistry detects three conformations of the lipid binding region of Escherichia coli pyruvate oxidase | journal = Biochemistry | volume = 36 | issue = 39 | pages = 11564–73 | date = September 1997 | pmid = 9305946 | doi = 10.1021/bi9709102 }}</ref><ref>{{cite journal | vauthors = O'Brien TA, Schrock HL, Russell P, Blake R, Gennis RB | title = Preparation of Escherichia coli pyruvate oxidase utilizing a thiamine pyrophosphate affinity column | journal = Biochimica et Biophysica Acta (BBA) - Enzymology | volume = 452 | issue = 1 | pages = 13–29 | date = November 1976 | pmid = 791368 | doi = 10.1016/0005-2744(76)90054-1 }}</ref><ref>{{cite journal | vauthors = Bertagnolli BL, Hager LP | title = Role of flavin in acetoin production by two bacterial pyruvate oxidases | journal = Archives of Biochemistry and Biophysics | volume = 300 | issue = 1 | pages = 364–71 | date = January 1993 | pmid = 8424670 | doi = 10.1006/abbi.1993.1049 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[pyruvate]] + [[ubiquinone]] + H<sub>2</sub>O <math>\rightleftharpoons</math> [[acetate]] + CO<sub>2</sub> + [[ubiquinol]]

This bacterial enzyme is located on the inner surface of the [[cytoplasmic membrane]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Pyruvate+dehydrogenase+(quinone)}}

{{Aldehyde/Oxo oxidoreductases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 1.2.5]]