View source for Precorrin-6Y C5,15-methyltransferase (decarboxylating)

{{infobox enzyme
| Name       = precorrin-6Y C5,15-methyltransferase (decarboxylating)
| EC_number  = 2.1.1.132
| CAS_number =
| GO_code    = 0046025
| image      = 
| width      = 
| caption    =  
}}
In [[enzymology]], a '''precorrin-6Y C5,15-methyltransferase (decarboxylating)''' ({{EC number|2.1.1.132}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:2 S-adenosyl-L-methionine + precorrin-6Y <math>\rightleftharpoons</math> 2 S-adenosyl-L-homocysteine + precorrin-8X + CO<sub>2</sub>
:[[File:Precorrin-6B to precorrin-8.svg|650px]]
The two [[substrate (biochemistry)|substrates]] of this enzyme are [[S-Adenosyl methionine|S-adenosyl methionine]] and [[precorrin 6Y]]; its three [[product (chemistry)|products]] are [[S-adenosylhomocysteine]], [[precorrin 8X]], and [[carbon dioxide|CO<sub>2</sub>]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring one-carbon group methyltransferases.  The [[List of enzymes|systematic name]] of this enzyme class is '''S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)'''. Other names in common use include '''precorrin-6 methyltransferase''', '''precorrin-6Y methylase''' and '''CobL'''. This enzyme is part of the biosynthetic pathway to [[cobalamin biosynthesis|cobalamin]] (vitamin B<sub>12</sub>) in [[Aerobic organism|aerobic]] [[bacteria]].

==See also==
* [[Cobalamin biosynthesis]]

==References==
{{reflist|1}}
* {{cite journal |vauthors=Blanche F, Famechon A, Thibaut D, Debussche L, Cameron B, Crouzet J | date = 1992 | title = Biosynthesis of vitamin B12 in Pseudomonas denitrificans: the biosynthetic sequence from precorrin-6y to precorrin-8x is catalyzed by the cobL gene product | journal = J. Bacteriol.  | volume = 174 | pages = 1050&ndash;2  | pmid = 1732195 | issue = 3 | pmc = 206191 }}

{{One carbon transferases}}
{{Enzymes}}
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[[Category:EC 2.1.1]]
[[Category:Enzymes of unknown structure]]


{{2.1-enzyme-stub}}