View source for Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

{{Short description|Phosphatase enzyme}}
{{Infobox enzyme
| Name       = Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
| EC_number  = 3.1.3.86
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase''' (EC 3.1.3.86, '''SHIP, p150Ship''') is an [[enzyme]] with [[List of enzymes|systematic name]] '''1-phosphatidyl-1<small>D</small>-''myo''-inositol-3,4,5-trisphosphate 5-phosphohydrolase''',<ref>{{cite journal | vauthors = Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR | title = p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity | journal = Genes & Development | volume = 10 | issue = 9 | pages = 1084–95 | date = May 1996 | pmid = 8654924 | doi = 10.1101/gad.10.9.1084 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G | title = The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 4 | pages = 1689–93 | date = February 1996 | pmid = 8643691 | pmc = 40003 | doi = 10.1073/pnas.93.4.1689 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H | title = Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 26857–63 | date = October 1997 | pmid = 9341117 | doi = 10.1074/jbc.272.43.26857 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C | title = Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase | journal = Biochemical and Biophysical Research Communications | volume = 225 | issue = 1 | pages = 243–9 | date = August 1996 | pmid = 8769125 | doi = 10.1006/bbrc.1996.1161 }}</ref><ref>{{cite journal | vauthors = Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C | title = The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity | journal = FEBS Letters | volume = 437 | issue = 3 | pages = 301–3 | date = October 1998 | pmid = 9824312 | doi = 10.1016/S0014-5793(98)01255-1 | doi-access = free }}</ref> that has two isoforms: SHIP1 (produced by the gene [[INPP5D]]) and SHIP2 ([[INPPL1]]).

This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 1-phosphatidyl-1<small>D</small>-''myo''-inositol 3,4,5-trisphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math><br> 1-phosphatidyl-1<small>D</small>-''myo''-inositol 3,4-bisphosphate + [[phosphate]]

This enzyme hydrolyses 1-phosphatidyl-1<small>D</small>-''myo''-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P<sub>3</sub>) to produce PtdIns(3,4)P<sub>2</sub>.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Phosphatidylinositol-3,4,5-trisphosphate+5-phosphatase}}

{{Esterases}}
{{Enzymes}}
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[[Category:EC 3.1.3]]