View source for Nitric oxide reductase (NAD(P), nitrous oxide-forming)

{{Infobox enzyme
| Name       = Nitric oxide reductase (NAD(P), nitrous oxide-forming)
| EC_number  = 1.7.1.14
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Nitric oxide reductase (NAD(P), nitrous oxide-forming)''' ({{EC number|1.7.1.14}}, ''fungal nitric oxide reductase'', ''cytochrome P450nor'', ''NOR (ambiguous)'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''nitrous oxide:NAD(P) oxidoreductase''.<ref>{{cite journal | vauthors = Shoun H, Tanimoto T | title = Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 11078–82 | date = June 1991 | pmid = 2040619 }}</ref><ref>{{cite journal | vauthors = Shiro Y, Fujii M, Iizuka T, Adachi S, Tsukamoto K, Nakahara K, Shoun H | title = Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism | journal = The Journal of Biological Chemistry | volume = 270 | issue = 4 | pages = 1617–23 | date = January 1995 | pmid = 7829493 }}</ref><ref>{{cite journal | vauthors = Zhang L, Kudo T, Takaya N, Shoun H | title = The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33842–7 | date = September 2002 | pmid = 12105197 | doi = 10.1074/jbc.M203923200 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Oshima R, Fushinobu S, Su F, Zhang L, Takaya N, Shoun H | title = Structural evidence for direct hydride transfer from NADH to cytochrome P450nor | journal = Journal of Molecular Biology | volume = 342 | issue = 1 | pages = 207–17 | date = September 2004 | pmid = 15313618 | doi = 10.1016/j.jmb.2004.07.009 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: N<sub>2</sub>O + NAD(P)<sup>+</sup> + {{chem|H|2|O}} <math>\rightleftharpoons</math> 2 NO + NAD(P)H + H<sup>+</sup>

This enzyme is heme-thiolate protein (P450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|Nitric+oxide+reductase+(NAD(P),+nitrous+oxide-forming)}}

{{Nitrogenous donor oxidoreductases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 1.7.1]]