View source for N2-citryl-N6-acetyl-N6-hydroxylysine synthase

{{Short description|Class of enzymes}}
{{DISPLAYTITLE:''N''<sup>2</sup>-citryl-''N''<sup>6</sup>-acetyl-''N''<sup>6</sup>-hydroxylysine synthase}}
{{Infobox enzyme
| Name       = ''N''<sup>2</sup>-citryl-''N''<sup>6</sup>-acetyl-''N''<sup>6</sup>-hydroxylysine synthase
| EC_number  = 6.3.2.38
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''''N''<sup>2</sup>-citryl-''N''<sup>6</sup>-acetyl-''N''<sup>6</sup>-hydroxylysine synthase''' ({{EnzExplorer|6.3.2.38}}, '''N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase''', '''iucA (gene)''') is an [[enzyme]] with [[List of enzymes|systematic name]] ''citrate:N<sup>6</sup>-acetyl-N<sup>6</sup>-hydroxy-L-lysine ligase (ADP-forming)''.<ref>{{cite journal | title = Aerobactin synthesis in a cell-free system of ''Aerobacter aerogenes'' 62-1 | vauthors = Appanna DL, Grundy BJ, Szczepan EW, Viswanatha T |journal = Biochim. Biophys. Acta |year = 1984 |volume = 801 | issue = 3 |pages = 437–443 |doi=10.1016/0304-4165(84)90150-8}}</ref><ref>{{cite journal | vauthors = Gibson F, Magrath DI | title = The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I | journal = Biochimica et Biophysica Acta (BBA) - General Subjects | volume = 192 | issue = 2 | pages = 175–84 | date = November 1969 | pmid = 4313071 | doi = 10.1016/0304-4165(69)90353-5 }}</ref><ref>{{cite journal | title = Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid, ''N''<sup>6</sup>-acetyl-''N''<sup>6</sup>-hydroxylysine | vauthors = Maurer PJ, Miller M |journal = J. Am. Chem. Soc. |year = 1982 |volume = 104 | issue = 11 |pages = 3096–3101 |doi=10.1021/ja00375a025}}</ref><ref>{{cite journal | vauthors = de Lorenzo V, Bindereif A, Paw BH, Neilands JB | title = Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12 | journal = Journal of Bacteriology | volume = 165 | issue = 2 | pages = 570–8 | date = February 1986 | doi = 10.1128/jb.165.2.570-578.1986 | pmid = 2935523 | pmc = 214457 }}</ref><ref>{{cite journal | vauthors = Challis GL | title = A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases | journal = ChemBioChem | volume = 6 | issue = 4 | pages = 601–11 | date = April 2005 | pmid = 15719346 | doi = 10.1002/cbic.200400283 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 2 ATP + [[citrate]] + N<sup>6</sup>-acetyl-N<sup>6</sup>-hydroxy-L-lysine + H<sub>2</sub>O <math>\rightleftharpoons</math> 2 ADP + 2 [[phosphate]] + N<sup>2</sup>-citryl-N<sup>6</sup>-acetyl-N<sup>6</sup>-hydroxy-L-lysine

This enzyme requires Mg<sup>2+</sup>.

== References ==
{{reflist}}

== External links ==
* {{MeshName|N2-citryl-N6-acetyl-N6-hydroxylysine+synthase}}

{{Ligases CO CS and CN}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 6.3.2]]