View source for Imidazoleacetate—phosphoribosyldiphosphate ligase

{{infobox enzyme
| Name       = Imidazoleacetate—phosphoribosyldiphosphate ligase
| EC_number  = 6.3.4.8
| CAS_number = 37318-65-3
| GO_code    = 0047483
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], an '''imidazoleacetate—phosphoribosyldiphosphate ligase''' ({{EnzExplorer|6.3.4.8}}) is an [[enzyme]] that [[catalysis|catalyzes]] a [[chemical reaction]]

:ATP + imidazole-4-acetate + 5-phosphoribosyl diphosphate <math>\rightleftharpoons</math> ADP + phosphate + 1-(5-phosphoribosyl)imidazole-4-acetate + diphosphate

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[imidazole-4-acetate]], and [[5-phosphoribosyl diphosphate]], whereas its 4 [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]], [[phosphate]], [[1-(5-phosphoribosyl)imidazole-4-acetate]], and [[diphosphate]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds.  The [[List of enzymes|systematic name]] of this enzyme class is '''imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming)'''. This enzyme is also called '''5-phosphoribosylimidazoleacetate synthetase'''.  This enzyme participates in [[histidine metabolism]].

== References ==
{{reflist|1}}
* {{cite journal | vauthors = Crowley GM | title = The enzymatic synthesis of 5'-phosphoribosylimidazoleacetic acid | journal = The Journal of Biological Chemistry | volume = 239 | pages = 2593–601 | date = August 1964 | pmid = 14235540 }}

{{Ligases CO CS and CN}}
{{Enzymes}}
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{{DEFAULTSORT:Imidazoleacetate-phosphoribosyldiphosphate ligase}}
[[Category:EC 6.3.4]]
[[Category:Enzymes of unknown structure]]


{{6.3-enzyme-stub}}