View source for Hepatic fructokinase

{{Short description|Class of enzymes}}
{{protein
|Name=ketohexokinase (fructokinase)
|caption= Ketohexokinase homodimer, Human
|image= 6ul7.jpg
|width= 270
|HGNCid=6315
|Symbol=KHK
|AltSymbols=
|EntrezGene=3795
|OMIM=229800
|RefSeq=NM_006488
|UniProt=P50053
|PDB=
|ECnumber=2.7.1.3
|Chromosome=2
|Arm=p
|Band=23.3
|LocusSupplementaryData=-23.2
}}
{{Infobox enzyme
| Name       = Ketohexokinase
| EC_number  = 2.7.1.3
| CAS_number = 9030-50-6
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
'''Hepatic fructokinase''' (or '''ketohexokinase''') is an [[enzyme]] that catalyzes the [[phosphorylation]] of [[fructose]] to produce [[fructose-1-phosphate]].

:'''ATP''' + [[File:Beta-D-Fructofuranose.svg|100px|Fru]] &nbsp;<math>\longrightarrow</math>&nbsp; '''ADP''' + [[File:Beta-D-Fructose-1-phosphat.svg|100px|F1P]]
:[[Adenosine triphosphate|ATP]] + D-fructose → [[Adenosine diphosphate|ADP]] + D-fructose-1-phosphate<ref name="pmid2996495">{{cite journal |vauthors=Bais R, James HM, Rofe AM, Conyers RA |title=The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol |journal=Biochem. J. |volume=230 |issue=1 |pages=53–60 |year=1985 |pmid=2996495 |doi= 10.1042/bj2300053|pmc=1152585}}</ref>

==Pathology==
A deficiency is associated with [[essential fructosuria]].

==References==
<references />

==External links==
* {{MeshName|Hepatic+fructokinase}}

{{Fructose and galactose metabolism}}
{{Kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 2.7.1]]


{{2.7-enzyme-stub}}