View source for Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase

{{infobox enzyme
| Name       = guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase
| EC_number  = 3.1.7.2
| CAS_number = 70457-12-4
| GO_code    = 0008893
| image      =
| width      = 
| caption    =  
}} 
The enzyme '''guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase''' (EC 3.1.7.2)<ref>{{cite journal | vauthors = Heinemeyer EA, Richter D | date = 1978 | title = Characterization of the guanosine 5'-triphosphate 3′-diphosphate and guanosine 5′-diphosphate 3′-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from ''Escherichia coli'' | journal = Biochemistry  | volume = 17 | pages = 5368&ndash;72  | pmid = 365225 | doi = 10.1021/bi00618a007 | issue = 25 }}</ref><ref>{{cite journal | vauthors = Richter D, Fehr S, Harder R | date = 1979 | title = The guanosine 3′,5′-bis(diphosphate) (ppGpp) cycle. Comparison of synthesis and degradation of guanosine 3′,5′-bis(diphosphate) in various bacterial systems | journal = Eur. J. Biochem.  | volume = 99 | pages = 57&ndash;64  | pmid = 114395 | doi = 10.1111/j.1432-1033.1979.tb13230.x | issue = 1 | doi-access = free }}</ref> [[catalysis|catalyzes]] the reaction

:guanosine 3′,5′-bis(diphosphate) + H<sub>2</sub>O <math>\rightleftharpoons</math> GDP + diphosphate

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on diphosphoric [[ester|monoester]] bonds.  The [[List of enzymes|systematic name]] is '''guanosine-3′,5′-bis(diphosphate) 3′-diphosphohydrolase'''. Other names in common use include '''guanosine-3′,5′-bis(diphosphate) 3′-pyrophosphatase''', '''PpGpp-3'-pyrophosphohydrolase''', and '''PpGpp phosphohydrolase'''.  This enzyme participates in [[purine metabolism]].

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1VJ7}}.

==References==
{{reflist|35em}}

{{Esterases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 3.1.7]]
[[Category:Enzymes of known structure]]


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