View source for DNA ligase (NAD+)

{{Infobox enzyme
| Name       = DNA ligase (NAD<sup>+</sup>)
| EC_number  = 6.5.1.2
| CAS_number = 37259-52-2
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
'''DNA ligase (NAD<sup>+</sup>)''' ({{EnzExplorer|6.5.1.2}}, ''polydeoxyribonucleotide synthase (NAD<sup>+</sup>)'', ''polynucleotide ligase (NAD<sup>+</sup>)'', ''DNA repair enzyme'', ''DNA joinase'', ''polynucleotide synthetase (nicotinamide adenine dinucleotide)'', ''deoxyribonucleic-joining enzyme'', ''deoxyribonucleic ligase'', ''deoxyribonucleic repair enzyme'', ''deoxyribonucleic joinase'', ''DNA ligase'', ''deoxyribonucleate ligase'', ''polynucleotide ligase'', ''deoxyribonucleic acid ligase'', ''polynucleotide synthetase'', ''deoxyribonucleic acid joinase'', ''DNA-joining enzyme'', ''polynucleotide ligase (nicotinamide adenine dinucleotide)'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)''.<ref>{{cite journal | vauthors = Zimmerman SB, Little JW, Oshinsky CK, Gellert M | title = Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 57 | issue = 6 | pages = 1841–8 | date = June 1967 | pmid = 4291949 | pmc = 224555 | doi = 10.1073/pnas.57.6.1841 | bibcode = 1967PNAS...57.1841Z | doi-access = free }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: NAD<sup>+</sup> + (deoxyribonucleotide)<sub>n</sub> + (deoxyribonucleotide)<sub>m</sub> <math>\rightleftharpoons</math> AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)<sub>n+m</sub>

Catalyses the formation of a [[phosphodiester]] at the site of a single-strand break in duplex DNA.

== See also ==
* [[DNA ligase]]

== References ==
{{reflist}}

== External links ==
* {{MeshName|DNA+ligase+(NAD+)}}

{{Phosphoric ester and nitrogen-metal ligases}}
{{Enzymes}}
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[[Category:EC 6.5.1]]


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