View source for Cob(II)yrinic acid a,c-diamide reductase

{{infobox enzyme
| Name       = cob(II)yrinic acid a,c-diamide reductase
| EC_number  = 1.16.8.1
| CAS_number =
| GO_code    = 0043784
| image      = 
| width      = 
| caption    =  
}}
In [[enzymology]], a '''cob(II)yrinic acid a,c-diamide reductase''' ({{EC number|1.16.8.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

[[File:Cob(II)yrinic acid a,c-diamide reductase.svg|480px|center]]

<div align=center>2 cob(I)yrinic acid a,c-diamide + FMN + 3 H<sup>+</sup> <math>\rightleftharpoons</math> 2 cob(II)yrinic acid a,c-diamide + FMNH<sub>2</sub></div>

The three [[substrate (biochemistry)|substrates]] of this enzyme are [[cob(I)yrinic acid a,c-diamide]], [[flavin mononucleotide]], and [[hydrogen ion|H<sup>+</sup>]]; its two [[product (chemistry)|products]] are [[cob(II)yrinic acid a,c-diamide]] and FMNH2.

== Classification ==

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those oxidizing metal ion with a flavin as acceptor.

== Nomenclature ==

The [[List of enzymes|systematic name]] of this enzyme class is '''cob(I)yrinic acid-a,c-diamide:FMN oxidoreductase'''. This enzyme is also called '''CobR''' and '''cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase (incorrect)'''.

== Biological role ==

This enzyme is part of the biosynthetic pathway to [[cobalamin]] (vitamin B<sub>12</sub>) in [[bacteria]].

==See also==
* [[Cobalamin biosynthesis]]

==References==

{{reflist|1}}
* {{cite journal | vauthors = Blanche F, Maton L, Debussche L, Thibaut D | date = 1992 | title = Purification and characterization of Cob(II)yrinic acid a,c-diamide reductase from Pseudomonas denitrificans | journal = J. Bacteriol.  | volume = 174 | pages = 7452&ndash;4  | pmid = 1429467 | issue = 22 | pmc = 207442 }}
* {{cite journal | vauthors = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | date = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B<sub>12</sub>) | journal = Nat. Prod. Rep.  | volume = 19 | pages = 390&ndash;412  | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}

{{Other oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.16.8]]
[[Category:Enzymes of unknown structure]]


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