View source for CDP-4-dehydro-6-deoxyglucose reductase

{{infobox enzyme
| Name       = CDP-4-dehydro-6-deoxyglucose reductase
| EC_number  = 1.17.1.1
| CAS_number = 37256-87-4
| GO_code    = 0047099
| image      =
| width      = 
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'''CDP-4-dehydro-6-deoxyglucose reductase''' ({{EC number|1.17.1.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:CDP-4-dehydro-3,6-dideoxy-D-glucose + NAD(P)<sup>+</sup> + H<sub>2</sub>O <math>\rightleftharpoons</math> CDP-4-dehydro-6-deoxy-D-glucose + NAD(P)H + H<sup>+</sup>

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[CDP-4-dehydro-3,6-dideoxy-D-glucose]], [[nicotinamide adenine dinucleotide]] ion, [[nicotinamide adenine dinucleotide phosphate]] ion, and [[water]], whereas its 4 [[product (chemistry)|products]] are [[CDP-4-dehydro-6-deoxy-D-glucose]], nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and [[hydrogen ion]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on CH or CH<sub>2</sub> groups with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)<sup>+</sup> 3-oxidoreductase'''. Other names in common use include '''CDP-4-keto-6-deoxyglucose reductase''', '''cytidine diphospho-4-keto-6-deoxy-D-glucose reductase''', '''cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase''', '''CDP-4-keto-deoxy-glucose reductase''', '''CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system''', and '''NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase'''. This enzyme participates in [[starch and sucrose metabolism]].

==References==
{{reflist|1}}
* {{cite journal |vauthors=Pape H, Strominger JL | year = 1969 | title = Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. V. Partial purification of the two protein components required for introduction of the 3-deoxy group | journal = J. Biol. Chem. | volume = 244 | pages = 3598&ndash;604 | pmid = 4389672 | issue = 13 }}
* {{cite journal |vauthors=Rubenstein PA, Strominger JL | year = 1974 | title = Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 8. Mechanistic roles of enzyme E-1 and pyridoxamine 5'-phosphate in the formation of cytidine diphosphate-4-keto-3,6-dideoxy-D-glucose from cytidine diphosphate-4-keto-6-deoxy-D-glucose | journal = J. Biol. Chem. | volume = 249 | pages = 3776&ndash;81 | pmid = 4152100 | issue = 12 }}
* {{cite journal |vauthors=Liu HW, Thorson JS | year = 1994 | title = Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria | journal = Annu. Rev. Microbiol. | volume = 48 | issue = 1 | pages = 223&ndash;56 | pmid = 7826006 | doi = 10.1146/annurev.mi.48.100194.001255 }}

{{Other oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.17.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]