View source for Biotin—(methylmalonyl-CoA-carboxytransferase) ligase

{{infobox enzyme
| Name       = Biotin—[methylmalonyl-CoA-carboxytransferase] ligase
| EC_number  = 6.3.4.9
| CAS_number = 37318-66-4
| GO_code    = 0004079
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''biotin—[methylmalonyl-CoA-carboxytransferase] ligase''' ({{EnzExplorer|6.3.4.9}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase] <math>\rightleftharpoons</math> AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]], [[biotin]], and [[apo-[methylmalonyl-CoA:pyruvate carboxytransferase]]], whereas its 3 [[product (chemistry)|products]] are [[adenosine monophosphate|AMP]], [[diphosphate]], and [[methylmalonyl-CoA:pyruvate carboxytransferase]].

This enzyme belongs to the family of [[ligase]]s, specifically those forming generic carbon-nitrogen bonds.  The [[List of enzymes|systematic name]] of this enzyme class is '''biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming)'''. <!--Other names in common use include '''biotin-[methylmalonyl-CoA-carboxyltransferase] synthetase''', '''biotin-methylmalonyl coenzyme A carboxyltransferase synthetase''', '''biotin-transcarboxylase synthetase''', '''methylmalonyl coenzyme A holotranscarboxylase synthetase''', '''biotin-[methylmalonyl-CoA-carboxyltransferase] ligase''', '''biotin:apo[methylmalonyl-CoA:pyruvate carboxyltransferase] ligase''', and '''(AMP-forming)'''. What is the evidence that all these names are common use? Citations needed-->  This enzyme participates in [[biotin metabolism]].

==References==
{{reflist|1}}
* {{cite journal |vauthors=Lane MD, Young DL, Lynen F | year = 1964 | title = The enzymatic synthesis of holotranscarboxylase from apotranscarboxylase and (+)-biotin. I. Purification of the apoenzyme and synthetase; characteristics of the reaction | journal = J. Biol. Chem.  | volume = 239 | pages = 2858&ndash;2864 }}

{{Ligases CO CS and CN}}
{{Enzymes}}
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{{DEFAULTSORT:Biotin-(methylmalonyl-CoA-carboxytransferase) ligase}}
[[Category:EC 6.3.4]]
[[Category:Enzymes of unknown structure]]


{{6.3-enzyme-stub}}